Mouse model of oropharyngeal candidiasis

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New model of oropharyngeal candidiasis in mice.

We established a straightforward murine model of oropharyngeal candidiasis. Mice were immunosuppressed with cortisone acetate, anesthetized, and then inoculated by placing cotton wool balls saturated with Candida albicans sublingually for 2 h. A prolonged, reproducible infection was induced. This model may be useful for antifungal screening or pathogenesis studies.

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ژورنال

عنوان ژورنال: Nature Protocols

سال: 2012

ISSN: 1754-2189,1750-2799

DOI: 10.1038/nprot.2012.011